DEPENDENCE OF THE BIOSYNTHETIC ABILITY OF THE PRODUCERS OF BIOLOGICALLY ACTIVE SUBSTANCES ON QUALITY OF NUTRIENT MEDIUM AND SUBSTRATUM

Inna Mihaylivna ZUBAREVA, Nataliia Borisivna MITINA, Anastasia Vadimivna VASILKOVA

Abstract

The  need  for  formulations  of  biologically  active  substances  of  natural  origin  currently increasing.The industrial production of such products biotechnological method important, but limited by a number of unsolved problems and shortcomings. So, this paper studied the effect of the qualitative composition  of  culture  media  and  substrates  for  biosynthetic  activity  and carotene  producing filamentous  proteins  and  red  Californian  worm  -  producing  biologically  active  substances  and  feed protein. Producers  offered  for  mycelial  growth  medium containing  a  carbon  source  enzymatic hydrolysates  flour  of  various  grains,  and  as  a  source  of  nitrogen  gluten  or  soy  milk. Found  that filamentous  organisms  -  producers  of  carotenoids  and  proteins  accumulate  high  amounts  of  both
biomass and target metabolites on nutrient media  containing hydrolysates of buckwheat, oat or corn flour in the presence of gluten. Used for the cultivation of vermiculture modified sunflower husk, which Eisenia  foetida,  as  a  producer  of  protein  drugs  and  medical  fodder  has  balanced  essential  amino acids,  vitamins,  enzymes  and  trace  element composition  of  the  biomass.These  results  show  that  the optimization of culture media and substrates provides increased biomass yield and biologically active substances in the few times producers of various taxonomic groups.

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